Ivo Bhuruu Vanhu veKentucky - mhuri kubva munhoroondo yeKetucky avo vaiwanzozvarwa vaine husingawanzo uye husingazivikanwe hutachiona hwakakonzera makanda avo kuita bhuruu.
Kweanoda kusvika mazana maviri emakore, "vanhu vane ganda rebhuruu vemhuri yevaFugate" vaigara munzvimbo dzeTroublesome Creek neBall Creek muzvikomo zvekumabvazuva kweKentucky. Ivo pakupedzisira vakapfuura yavo yakasarudzika hunhu kubva kuchizvarwa kuenda kuchizvarwa, vakasara zvakanyanya vari vega kubva kunze kwenyika. Ivo vanozivikanwa zvakanyanya se "Blue People yeKentucky."
Iyo nyaya yeBlue People yeKentucky
Kune nyaya mbiri dzinoenderana nezvemurume wekutanga Akarukwa neBlue muBlue mumhuri yeKentucky. Zvakadaro, vese vanoti zita rimwe chete, "Martin Fugate" kuve munhu wekutanga Blue Skinned uye kuti aive murume akaberekerwa kuFrance aive nherera achiri mudiki uye akazogarisa mhuri yake pedyo neHazard, Kentucky, kuUnited States.
Mumazuva iwayo, nyika ino yekumabvazuva kweKentucky yaive nzvimbo yekumaruwa yaive kure kwaigara mhuri yaMartin nedzimwe mhuri dzepedyo. Pakanga pasina migwagwa, uye njanji yaisatombosvika kunzvimbo iyoyo yenyika kusvika kutanga kwema1910. Naizvozvo, roorano pakati pemhuri yaive tsika yakajairika pakati pevanhu vanogara munharaunda iyoyo iri kure yeKentucky.
Idzi nyaya mbiri dzinouya nematanho akafanana asi mutsauko chete watakawana uri munhambo yavo yenguva iyo yakataurwa muchidimbu apa pazasi:
Nyaya yekutanga yeBlue People yeKentucky
Iyi nyaya inotaurira kuti Martin Fugate akararama munguva yekutanga kwezana ramakore regumi nemapfumbamwe uyo akaroora Elizabeth Smith, mukadzi anobva kumhuri iripedyo iyo maFugates akaroora naye. Iye akanzi akacheneruka uye akachena kunge gomo raurel iro rinotumbuka wega wega chitubu chakakomberedza rukova makomba uye aive zvakare mutakuri weiyi bhuruu yeganda genetic disorder. Martin naElizabeth vakatanga kuchengetedza dzimba kumahombekombe eDambudziko uye vakatanga mhuri yavo. Pakati pevana vavo vanomwe, vana vanonzi vaive bhuruu.
Gare gare, maFugates akaroora mamwe maFugates. Dzimwe nguva vairoora vekutanga hama uye vanhu vaigara padhuze navo. Mhuri yakaramba ichiwanda. Nekuda kweizvozvo, vazukuru vazhinji vevaFugates vakazvarwa vaine chirwere chebhuruu reganda kusagadzikana uye vakaramba vachirarama munzvimbo dzakatenderedza Troublesome Creek neBall Creek muzana ramakore rechi20.
Nyaya yechipiri yeBlue People yeKentucky
Ipo, imwe nyaya inosimbisa kuti paive nevanhu vatatu vainzi Martin Fugate mune iyo Fugates Mhuri muti. Ivo vakazorarama pakati pa1700 na1850, uye wekutanga bhuruu Skinned munhu aive wechipiri akararama munguva yekupera kwegumi nemasere century kana 1750 mumashure. Akange akaroora Mary Wells aive zvakare mutakuri wechirwere ichi.
Mune ino nyaya yechipiri, Martin Fugate akataura munyaya yekutanga uyo aigara mukutanga kwezana ramakore rechigumi nemapfumbamwe uye akaroora kuna Elizabeth Smith anga asiri munhu ane ganda-rebhuruu zvachose. Nekudaro, hunhu hwaElizabeth hunoramba hwakafanana, sezvo aive iye anotakura chirwere ichi chataurwa murungano rekutanga, uye yasara yenyaya yechipiri inenge yakafanana nenyaya yekutanga.
Chii chaizvo chakaitika kune vanhu vane ganda rebhuruu veTrustlesome Creek?
Vese vevaFugates zvinoshamisa vakararama makore makumi masere nemakumi mapfumbamwe nemapfumbamwe vasina chero chirwere kana rimwe dambudziko rehutano kunze kweiri bhuruu reganda jeni-kusagadzikana kwakakanganisa zvakanyanya mararamiro avo. Vakanga vachinyara chaizvo nezvekuva bhuruu. Paigara paine fungidziro mumakomba pamusoro pezvaiita kuti vanhu vebhuruu vave bhuruu: chirwere chemwoyo, chirwere chemapapu, mukana wakataurwa nemumwe wekare kuti "ropa ravo riri padyo padyo neganda ravo." Asi hapana ainyatsoziva, uye vanachiremba vaisawanzo shanyira kunzvimbo dziri kure dzekurukova uko vazhinji ve "Blue Fugates" vaigara kusvika kusvika kuma85.
Panguva iyoyo maFugates maviri akasvika Madison Cawein III, mudiki chiremba wezvematambudziko paYunivhesiti yeKentucky yekiriniki yezvehutano panguva iyoyo, mukutsvaga mushonga.
Achishandisa tsvakiridzo yakaunganidzwa kubva kuzvidzidzo zvake zvekare zve yakasarudzika Alaskan Eskimo vanhu, Cawein akakwanisa kupedzisa kuti ivo vaFugates vakatakura chirwere chisingawanzoitika chekugara nhaka chinokonzera kuwanda kwemashemoglobin muropa ravo. Mamiriro aya anonzi Methemoglobinemia.
Methemoglobin iri isinga shande yebhuruu vhezheni ine hutano mutsvuku hemoglobin protein inotakura oxygen. Muvanhu vazhinji veCaucasus, iyo hemoglobin tsvuku yeropa mumitumbi yavo inoratidza kuburikidza neganda ravo ichichipa pink tint.
Munguva yekutsvaga kwake, methylene bhuruu yakabuda kundangariro yaCawein semushonga "unonyatso kuoneka". Vamwe vevanhu vebhuruu vakafunga kuti chiremba anga akawedzeredzwa nekufunga kuti dhayi yebhuruu inogona kuvashandura pink. Asi Cawein aiziva kubva kuzvidzidzo zvekare kuti muviri une imwe nzira yekushandura methemoglobin kuti ive yechinyakare. Kuishandisa kunoda kuwedzera muropa chinhu chinoshanda se "mupi wemagetsi." Zvinhu zvakawanda zvinoita izvi, asi Cawein akasarudza methylene bhuruu nekuti yainge yashandiswa zvinobudirira uye zvakachengeteka mune zvimwe zviitiko uye nekuti inoshanda nekukurumidza.
Cawein akapinza yega yega yevanhu vane ganda rebhuruu vane mamirigiramu zana emethylene bhuruu, izvo zvakarerutsa zviratidzo zvavo uye nekudzora ruvara rwebhuruu rweganda ravo mukati memaminetsi mashoma. Kwenguva yekutanga muhupenyu hwavo, vaive vakapinki uye vakafadzwa. Uye Cawein akapa mhuri yega yega yebhuruu kupihwa mahwendefa emethylene ebhuruu kuti atore semapiritsi ezuva nezuva nekuti izvo zvinokonzeresa zvemushonga ndezvenguva pfupi, sezvo methylene bhuruu inowanzo kubudiswa mumurini. Cawein akazoburitsa kutsvagurudza kwake mu Archives of Internal Medicine (Kubvumbi 100) muna 1964.
Mushure mepakati pezana ramakore rechimakumi maviri, sezvo kufamba kwakave nyore uye mhuri dzakapararira munzvimbo dzakapamhamha, kuwanda kwegenesis yakawandisa muhuwandu hwevagari kwakadzikira, uye pamwe nayo mukana wekugara nhaka chirwere.
Benjamin Stacy ndiye wekupedzisira anozivikanwa wedzinza revaFugates uyo akazvarwa muna 1975 aine hunhu hwebhuruu hweBlue Mhuri yeKentucky uye akarasikirwa neruvara rweganda rebhuruu paakakura. Kunyangwe nhasi Benjamin nevazhinji vemhuri yemhuri yeFugate varasikirwa neruvara rwebhuruu, iyo tint ichiri kubuda muganda ravo kana vachitonhora kana kuputira nehasha.
Dr. Madison Cawein vakafananidzira nyaya yakakwana yekuti maFugates vakagara nhaka chirwere chebhuruu ganda, vakatakura yakawandisa methemoglobinemia (met-H) geni kubva kuchizvarwa kuenda kuchizvarwa, uye akaitisa sei ongororo yake ikoko kuKentucky. Iwe unogona kudzidza zvakawanda nezve iyi inoshamisa nyaya pano.
Dzimwe zvimwe zviitiko zvakafanana
Paive nedzimwe nyaya mbiri dzemurume ane ganda-rebhuruu nekuda kwemetemoglobinaemia, inozivikanwa se "varume vebhuruu veLurgan". Vakanga vari vaviri vevarume veLurgan vaitambura nechakatsanangurwa se "mhuri idiopathic methaemoglobinaemia", uye vakarapwa naDr. James Deeny mugore ra1942. Deeny akarayira kosi ye ascorbic acid uye sodium bicarbonate. Muchiitiko chekutanga, nezuva rechisere rekurapa pakanga paine shanduko inoonekwa pakuonekwa, uye nezuva regumi nemaviri rekurapwa, chimiro chemurwere chaive chakajairika. Muchiitiko chechipiri, chimiro chemurwere chakasvika pane zvakajairika kwenguva refu yemwedzi-kurapwa.
Wanga uchiziva here kuti kuwana sirivheri kunogona zvakare kukonzera ganda redu kuita grey kana bhuruu uye ine chepfu kune vanhu?
Pane mamiriro anonzi Argyria kana argyrosis, inozivikanwawo se "Blue Man Syndrome," iyo inokonzereswa nekuratidzwa kwakanyanya kumakemikari macomputer e element element sirivheri kana guruva resirivheri. Chiratidzo chinonyanya kushamisa cheArgyria ndechekuti ganda rinoshandura bhuruu-yepepuru kana yepepuru-grey.
Mune mhuka nevanhu, kumedza kana kufema sirivha muhuwandu hwakawanda kwenguva yakareba kunowanzo kutungamira kuunganidzwa zvishoma nezvishoma kwemasirivheri masisitimu munzvimbo dzakasiyana dzemuviri izvo zvinogona kukonzera kuti dzimwe nzvimbo dzeganda nedzimwe nyama dzemuviri dzitsvuke kuchena kana bhuruu-grey.
Vanhu vanoshanda mumafekitori anogadzira zvigadzirwa zvesirivheri vanokwanisawo kufema nesirivha kana makomponi ayo, uye sirivheri inoshandiswa mune zvimwe zvekushandisa pakurapa nekuda kweayo anti-microbial hunhu. Nekudaro, Argyria haisi iyo inotyisidzira hupenyu mamiriro ekurapa uye zvinokwanisika kurapa kuburikidza nemishonga. Asi kunyanyisa kudya kwechero mhando yemakemikari kondinendi kunogona kuuraya kana kunogona kuwedzera njodzi dzehutano saka isu tinofanira kugara tichingwarira kuita chero chinhu seichi.
Mushure mekuverenga nezve "The Blue Of Kentucky," verenga nezve "Bionic UK Musikana Olivia Farnsworth Asinganzwe Nzara Kana Kurwadziwa!"
